Synephrine Hydrochloride Weight Loss Raw Materials 99% Pure

Product Description

Synephrine Hydrochloride Weight Loss Raw Materials 99% Pure

Description

Synephrine hydrochloride is an alkaloid that exists in a variety of plants (such as citrus aurantium, citrus peel, orange peel, tangerine peel), and is mainly used for weight loss products and health care products such as stomach and food.
Synephrine alias 1-(4-Hydroxyphenyl)-2-(methylamino)ethanol; Synephrine; Synephrine; Phenyl-2-methylaminoethanol; Deoxyepinephrine; p-Hydroxy-α-methylamine methyl benzyl alcohol; Phenolic hydroxyl and amino groups, so synephrine has amphoteric properties and can combine with acid and alkali to form salts.
Free synephrine is easily soluble in organic solvents but insoluble in water; its acid salts and basic salts are easily soluble in water but insoluble in organic solvents. Synephrine has been included in the Nordic Pharmacopoeia and the German Pharmacopoeia. It is currently considered to be an adrenergic alpha-receptor agonist. Synephrine has the effect of constricting blood vessels and increasing blood pressure.
Synephrine has a strong dilation of the trachea and bronchi. Intravenous injection in anesthetized cats can completely resist the bronchoconstriction caused by histamine, and it also has the same effect on isolated trachea of ​​guinea pigs. Synephrine is clinically used for the treatment of bronchial asthma and hypotension during surgery and anesthesia, collapse and shock, orthostatic hypotension, etc.
Synephrine is a natural stimulant in the 21st century without any side effects and positive reactions. It is widely used in medicine, food, beverage and other health care industries. With the ban of chemically synthesized drugs, the demand and value of synephrine will double.
L-Syphrine exists in limes and citrus, dry young fruit aurantium, green peel and other plants, and the content is only 0.28-2.53%. At present, the commercially available L-Syphrine products have low purity and many impurities, and cannot be used in high value-added fields such as medicine. Therefore, the development and preparation of high-purity L-syphrine has become the key in this field.

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【Pharmacological action and application】

Synephrine hydrochloride can be used as a vasopressor, for shock, for heart failure, for the treatment of bronchial asthma, and during surgery and anesthesia, as well as for bottom blood pressure, collapse and shock, hypotension, etc.; α-adrenergic receptors Agonists, vasoconstrictors, etc.

1. Cardiovascular effects

Intravenous injection of Citrus aurantium, Citrus Citrus decoction, Citrus Citrus extract, Citrus Citrus injection and its active ingredient synephrine hydrochloride can significantly enhance various indicators of myocardial contractility and pumping function in anesthetized dogs. Strengthen the heart, constrict blood vessels, increase total peripheral resistance, and increase left ventricular pressure and arterial blood pressure. Modern research has also confirmed that citrus aurantium can increase the tension of rabbit aorta in a concentration-dependent manner and make aortic smooth muscle contract.

2. The effect on weight loss

Synephrine hydrochloride acts as a weight loss promoter, and its mechanism of action is to stimulate β-3 adrenergic receptors to induce lipid breakdown and subsequent thermogenesis. Most dietary supplements containing synephrine hydrochloride also contain various other ingredients, primarily caffeine, salicylic acid, and ephedrine. The combination of the above-mentioned chemical components can improve the weight loss effect of synephrine hydrochloride. Taking rats as research subjects, repeated oral administration of commercially available hydroalcoholic lime extract with standardized content of synephrine hydrochloride to evaluate food intake and cardiovascular function, and found that lime extract can reduce food intake and weight gain, The electrocardiogram of the animals in the experimental group was abnormal.

3. Effects on blood pressure

In pharmacology synephrine hydrochloride is used as a decongestant, in the oral form to treat hypotension. To study the hemodynamic effects of dietary supplements containing lime extract in 10 healthy adults, demonstrating that some dietary supplements can increase blood pressure and cardiovascular stimuli in healthy, normotensive subjects, possibly It is produced in a multi-component formula in conjunction with caffeine and other stimulants. Animal studies have shown that synephrine hydrochloride and lime extract increase blood pressure. Taking lime extract (6% synephrine hydrochloride) and 8 ounces of fruit juice (containing approximately 13 to 14 mg synephrine hydrochloride) for six weeks did not find any significant effect on subjects' blood pressure, evaluation The effects of synephrine hydrochloride on blood pressure may require longer study periods. There are also reports in the literature that Sinfer has a significant boosting effect, enhancing myocardial contractility, slowing heart rate and increasing cardiac output, increasing coronary flow, and increasing renal blood flow.

4. Effect on diabetes

The effect of Citrus aurantium extract on the antioxidant defense function of the liver in experimental diabetic mice. The diabetic mice were treated with high, medium and low doses of Citrus aurantium extract, and the antioxidant capacity of the liver and the tissue morphology of the liver were observed. learning changes. Compared with the diabetes model group, the citrus fruit extract treatment group significantly decreased the blood glucose level (p < 0.05), the glutathione content increased significantly (p < 0.05), the glutathione peroxidase activity, malondialdehyde and The nitrogen oxide content decreased significantly (p < 0.01), and the superoxide dismutase activity increased. Under the light microscope, the liver tissue cell damage in the Citrus aurantium extract treatment group was lower than that in the diabetes group, indicating that the Citrus Citrus extract has the effect of enhancing the antioxidant capacity of the liver and reducing liver cell damage.

1. The effect on the bronchi

Intravenous synephrine hydrochloride completely counteracted histamine-induced bronchoconstriction by anesthetizing cats; it also had the same effect on isolated guinea pig organs.

2. Effects on depression

Some scholars have studied the antidepressant effect of p-synephrine hydrochloride by establishing a mouse tail suspension test and a mouse forced swimming test depression model. Taking the time of immobile disappointment as an indicator, the oral dose of 1-10mg/ kg (0.5 mL/25 g body weight), significantly reducing its immobility time. Mind-boosting drugs can reduce immobility time, but stimulate voluntary activity. The gavage dose of p-synephrine hydrochloride is 0.3-10 mg/kg. It is found that there is no significant change in voluntary activity in the open field experiment of mice, which excludes p- Psychostimulatory effects of synephrine hydrochloride. p-Synphrine hydrochloride has obvious antidepressant effect in the behavioral despair animal depression model, which can counteract its despairing behavior and reduce despairing behavior (immobility time), which may be related to the stimulation of α-1 adrenergic receptors. May have a therapeutic effect on antidepressant effects in hypotensive patients.

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1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
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