Avanafil CAS 330784-47-9 For The Treatment Of Erectile Dysfunction

Product Description

Avanafil CAS 330784-47-9 For The Treatment Of Erectile Dysfunction

Description

Avanafil is a new generation of phosphodiesterase type 5 (PDE5) inhibitor, which is similar to previous generations of sildenafil, tadalafil and vardenafil. The inhibition of PDE5 increases the level of cyclic guanosine monophosphate (cGMP), which promotes the relaxation of cavernosal smooth muscle and leads to increased blood perfusion and erection.
The use of PDE5 inhibitors can significantly improve the symptoms of ED, but there is no PDE5 gene and protein expression in the male testis, so the use of PDE5 inhibitors has no effect on sperm morphology and motility. Can be used for adjunctive treatment of male infertility without reproductive toxicity.

Commerce Clause

What are the characteristics of Avanafil?
Some people may wonder, we already have several PDE5 inhibitors, why develop avanafil? This is because Avanafil is different from other similar drugs in chemical structure and has its own unique advantages.

1. Fast onset of action: Avanafil has a fast onset of action, it will take effect about 15 minutes after oral administration, and the medication is not affected by diet. Compared with other similar drugs, sildenafil (60 minutes), tadalafil (25 minutes), and vardenafil (30 minutes), the use of avanafil can make oneself "prepared" faster.
2. Low adverse reactions: When using PED5 inhibitors, adverse reactions such as headache, flushing, nasal congestion, indigestion, back pain, visual disturbance, and hypotension are the biggest problems for patients. In clinical trials, avanafil had the lowest incidence of adverse reactions.
3. High safety: Among PDE5 inhibitors, avanafil has the fastest metabolism, which means that the drug is less likely to produce accumulated toxicity and is relatively safer.

What to watch out for while using avanafil
1. Dosage: Avanafil has two specifications, 100mg and 200mg. If it is used for the first time, it is recommended to choose a low dose of 100mg, which is only taken 15 minutes in advance.
According to the effect and tolerance after taking the drug, if the effect has not reached the ideal state, it can be increased to 200mg, or reduced to 50mg, and the frequency of dosing is once a day.
2. The key to the effect: Avanafil works by reducing the destruction of cGMP and increasing its level. However, sexual stimulation is required to promote the release of the vasoactive factor nitric oxide (NO) to activate the NO-cGMP molecular pathway. In other words, the onset of action after taking the drug requires sexual stimulation, otherwise the drug will not work.
3. Interaction with other drugs: Nitrates can promote the release of NO. When used in combination with avanafil, it will cause severe hypotension and should be disabled. For those who use avanafil, it is necessary to wait more than 12 hours before using nitrates.
Avanafil is metabolized by the hepatic drug enzyme CYP3A4, and if a CYP3A4 inhibitor (ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazole) is used concomitantly ketone, nelfinavir, saquinavir and telithromycin, etc.), avanafil needs to be banned.
4. Contraindications: Those who are allergic to this product and suffer from myocardial infarction, stroke or life-threatening arrhythmia within 6 months are prohibited; blood pressure is lower than 90/50mmHg, or higher than 170/100mmHg; severe angina pectoris , Severe hepatic and renal insufficiency is prohibited.
Contraindicated in patients with hereditary degenerative retinal disease and non-arteritic anterior ischemic neuropathy (NAION) causing monocular vision loss.

Our Company Advantages:

1, High quality with competitive price:

1) Standard: U.S Standard
2) All Purity≥99.8%
3) We are manufacturer and can provide high quality products with factory price.

FAQ

Question 1 , How do you pack the order ?
Discreet package , the packing suits you best would be choosen to cross customs safely

Question 2 , What is your shipping method ?
Shipping by express (FedEx,UPS,DHL,EMS,HKEMS,TNT), and cheapest by airmail

Question 3 , if my order seized by custom ,what do you do ?
Resending police if the tracking number do not update online or it sezied by custom

Questions 4 , What is your payment accept ?
Safe and fast payment :Western Union ,Money Gram ,T/T ,Bitcoin

Questions 5 , Will you supply tracking number ?
Yes ,we supply tracking number for following .In general ,once we supply the tracking number to you ,you can track the parcel information within 1-2 business days

Question 6 , How many days will it take to my country after I do the payment ?
In general ,fastest with 3-5 business , slowest 5-7 business days

Packaging & Service:

1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking number are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.
Please feel free to contact us. 24/7 online to solve your various problems!

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