|Place of Origin:||china|
Payment & Shipping Terms:
|Minimum Order Quantity:||1kg|
|Packaging Details:||Aluminum foil bag3|
|Payment Terms:||L/C, D/A, D/P|
|Type:||Hand Tools||Material:||Plastic,PP Or PET|
|Color:||White||Product Name:||Multi Function Classic Hand Car Repairing Tool Set|
|Package:||Case,color Box||Packing:||Opp Bag|
Sitagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor, which can be used alone or in combination with other oral hypoglycemic agents in the treatment of type 2 diabetes. It has the advantages of good safety and low incidence of adverse reactions such as hypoglycemia and weight gain.
Sitagliptin dipeptidyl peptidase 4 (DPP-4) inhibitors improve glycemic control by increasing levels of active islet hormone in patients with type 2 diabetes. Islet hormones include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulin-secreting peptide (GIP), which are released by the gut throughout the day and are elevated after a meal. Islet hormone is part of the endogenous system involved in the physiological regulation of glucose homeostasis. Glp-1 and GIP increase pancreatic β cell synthesis and insulin release through intracellular signaling pathways involving adenosine cyclophosphine when blood glucose levels are normal or elevated. In an animal model of type 2 diabetes, glP-1 or DPP-4 inhibitor therapy improves pancreatic beta cell responsiveness to glucose and promotes insulin biosynthesis and release. As insulin levels rise, the uptake of glucose by tissues increases. In addition, GLP-1 inhibits glucagon secretion by pancreatic α cells. A decrease in glucagon concentration and an increase in insulin levels can reduce hepatic glucose production, thereby lowering blood glucose levels. The effects of GLP-1 and GIP are glucose-dependent. Glp-1 does not promote insulin release or inhibit glucagon secretion when blood glucose concentration is low. Glp-1 and GIP enhanced insulin release when glucose levels were higher than normal. In addition, GLP-1 does not impair the body's normal glucagon release response to hypoglycemia. The activity of GLP-1 and GIP is limited by the enzyme DPP-4, which can rapidly hydrolyze islet hormone to produce inactive products. Sitagliptin prevents dPP-4 from hydrolyzing islet hormone, thereby increasing plasma concentrations of the active form OF GLP-1 and GIP. Sitagliptin increases insulin release and decreases glucagon levels in a glucose-dependent manner by increasing active trypsin levels. These changes in insulin and glucagon levels reduce glycosylated hemoglobin A1c (HbA1c) and fasting and postprandial glucose levels in type 2 diabetics with hyperglycemia. The glucose-dependent mechanism of action of sitagliptin differs from that of sulfonylureas, which increase insulin secretion even at low glucose levels, leading to hypoglycemia in patients with type 2 diabetes and normal subjects. Sitagliptin is a potent and highly selective inhibitor of DPP-4 enzyme that does not inhibit DPP-8 or DPP-9, which are closely related to DPP-4, at therapeutic concentrations.
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1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!
Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
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