Sitagliptin antidiabetics High purity

Product Description

Sitagliptin is a dipeptidyl peptidase 4 (DPP-4) inhibitor, which can be used alone or in combination with other oral hypoglycemic agents in the treatment of type 2 diabetes. It has the advantages of good safety and low incidence of adverse reactions such as hypoglycemia and weight gain.

Sitagliptin dipeptidyl peptidase 4 (DPP-4) inhibitors improve glycemic control by increasing levels of active islet hormone in patients with type 2 diabetes. Islet hormones include glucagon-like peptide-1 (GLP-1) and glucose-dependent insulin-secreting peptide (GIP), which are released by the gut throughout the day and are elevated after a meal. Islet hormone is part of the endogenous system involved in the physiological regulation of glucose homeostasis. Glp-1 and GIP increase pancreatic β cell synthesis and insulin release through intracellular signaling pathways involving adenosine cyclophosphine when blood glucose levels are normal or elevated. In an animal model of type 2 diabetes, glP-1 or DPP-4 inhibitor therapy improves pancreatic beta cell responsiveness to glucose and promotes insulin biosynthesis and release. As insulin levels rise, the uptake of glucose by tissues increases. In addition, GLP-1 inhibits glucagon secretion by pancreatic α cells. A decrease in glucagon concentration and an increase in insulin levels can reduce hepatic glucose production, thereby lowering blood glucose levels. The effects of GLP-1 and GIP are glucose-dependent. Glp-1 does not promote insulin release or inhibit glucagon secretion when blood glucose concentration is low. Glp-1 and GIP enhanced insulin release when glucose levels were higher than normal. In addition, GLP-1 does not impair the body's normal glucagon release response to hypoglycemia. The activity of GLP-1 and GIP is limited by the enzyme DPP-4, which can rapidly hydrolyze islet hormone to produce inactive products. Sitagliptin prevents dPP-4 from hydrolyzing islet hormone, thereby increasing plasma concentrations of the active form OF GLP-1 and GIP. Sitagliptin increases insulin release and decreases glucagon levels in a glucose-dependent manner by increasing active trypsin levels. These changes in insulin and glucagon levels reduce glycosylated hemoglobin A1c (HbA1c) and fasting and postprandial glucose levels in type 2 diabetics with hyperglycemia. The glucose-dependent mechanism of action of sitagliptin differs from that of sulfonylureas, which increase insulin secretion even at low glucose levels, leading to hypoglycemia in patients with type 2 diabetes and normal subjects. Sitagliptin is a potent and highly selective inhibitor of DPP-4 enzyme that does not inhibit DPP-8 or DPP-9, which are closely related to DPP-4, at therapeutic concentrations.

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3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!

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