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Saxagliptin antidiabetics cheap and fine

Product Details:
Place of Origin: china
Brand Name: jingyuan
Model Number: 20211020
Payment & Shipping Terms:
Minimum Order Quantity: 1kg
Price: 33000usd
Packaging Details: Aluminum foil bag3
Delivery Time: 10days
Payment Terms: L/C, D/A, D/P
Supply Ability: 100kg

Detail Information

Type: Hand Tools Material: Plastic,PP Or PET
Color: White Product Name: Multi Function Classic Hand Car Repairing Tool Set
Feature: Deformation Toys Power: Battery
Package: Case,color Box Packing: Opp Bag

Product Description

Saxagliptin antidiabetics cheap and fine

Saxagliptin ONGLYZA™ (Saxagliptin saxagliptin tablets) is a highly effective Dipeptidyl Peptidase 4 (DPP-4) inhibitor that selectively inhibits DPP-4, It can increase endogenous levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent Insulinotropic Peptide (GIP), thus regulating blood Glucose.Saxagliptin, Sax, a potent selective DPP-4 inhibitor, can specifically prolong the inhibition of DPP-4, thereby prolonging the duration of action of endogenous GLP-1 and GIP to reduce blood glucose. On May 5, 2011, Sax received marketing approval in China (trade name Enrizer) for the treatment of TZDM.
1. Pharmacological effects
The mechanism of action is that it works by blocking the degradation of GLP-1, a hormone naturally produced in the intestine after ingestion of food, which regulates insulin secretion and enhances glucose utilization in surrounding tissues.
2. Pharmacokinetics
The plasma concentrations of saxagliptin were dose-proportional and had similar pharmacokinetic parameters in healthy subjects and patients with type 2 diabetes. In patients with type 2 diabetes, saxagliptin inhibits DPP-4 activity for up to 24 h. Inhibition of dPP-4 by saxagliptin leads to a 2-3 fold increase in glP-1 and GIP activity after oral glucose or meal, and decreases glucagon concentration, increasing insulin secretion by pancreatic beta cells in a glucose-dependent manner. The time to reach the maximum plasma drug concentration was < 2 h, and the calculated mean half-life was 2.2-3.8 h. Further studies have shown that older subjects (≥ 65 years) receiving a single dose of 10 mg of saxagliptin have less than a twofold increase in exposure compared with younger subjects (18-40 years). Therefore, there is no need to adjust the dose of saxagliptin according to age.
Approximately 70% of saxagliptin can be recovered in urine, indicating that saxagliptin can be widely absorbed after oral administration. Saxagliptin can be cleared through metabolism (21% -- 52% of the dose administered is recovered in the urine as major metabolites) and renal excretion (12% -- 29% of the dose administered is cleared in the urine as mother drug). A recent study evaluated the effects of renal insufficiency and hemodialysis on the pharmacokinetics of saxagliptin. In this study, the degree of renal insufficiency did not affect the Cmax of saxagliptin or its major metabolites. The mean global systemic exposure (AUC) of saxagliptin and its major metabolites in subjects with mild renal insufficiency was 1.2 times and 1.7 times higher than that in subjects with normal renal insufficiency, respectively. AUC values were 1.4 and 2.9 times higher in subjects with moderate renal insufficiency than in subjects with normal renal function, respectively. The corresponding values were 2.1 and 4.5 times, respectively, in subjects with severe renal insufficiency. Hemodialysis at 4 h can remove 23% of the dose of Sax. [2]

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1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!

Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
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