|Place of Origin:||china|
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|Minimum Order Quantity:||1kg|
|Packaging Details:||Aluminum foil bag3|
|Payment Terms:||L/C, D/A, D/P|
|Type:||Hand Tools||Material:||Plastic,PP Or PET|
|Color:||White||Product Name:||Multi Function Classic Hand Car Repairing Tool Set|
|Package:||Case,color Box||Packing:||Opp Bag|
Saxagliptin antidiabetics cheap and fine
Saxagliptin ONGLYZA™ (Saxagliptin saxagliptin tablets) is a highly effective Dipeptidyl Peptidase 4 (DPP-4) inhibitor that selectively inhibits DPP-4, It can increase endogenous levels of glucagon-like peptide-1 (GLP-1) and glucose-dependent Insulinotropic Peptide (GIP), thus regulating blood Glucose.Saxagliptin, Sax, a potent selective DPP-4 inhibitor, can specifically prolong the inhibition of DPP-4, thereby prolonging the duration of action of endogenous GLP-1 and GIP to reduce blood glucose. On May 5, 2011, Sax received marketing approval in China (trade name Enrizer) for the treatment of TZDM.
1. Pharmacological effects
The mechanism of action is that it works by blocking the degradation of GLP-1, a hormone naturally produced in the intestine after ingestion of food, which regulates insulin secretion and enhances glucose utilization in surrounding tissues.
The plasma concentrations of saxagliptin were dose-proportional and had similar pharmacokinetic parameters in healthy subjects and patients with type 2 diabetes. In patients with type 2 diabetes, saxagliptin inhibits DPP-4 activity for up to 24 h. Inhibition of dPP-4 by saxagliptin leads to a 2-3 fold increase in glP-1 and GIP activity after oral glucose or meal, and decreases glucagon concentration, increasing insulin secretion by pancreatic beta cells in a glucose-dependent manner. The time to reach the maximum plasma drug concentration was < 2 h, and the calculated mean half-life was 2.2-3.8 h. Further studies have shown that older subjects (≥ 65 years) receiving a single dose of 10 mg of saxagliptin have less than a twofold increase in exposure compared with younger subjects (18-40 years). Therefore, there is no need to adjust the dose of saxagliptin according to age.
Approximately 70% of saxagliptin can be recovered in urine, indicating that saxagliptin can be widely absorbed after oral administration. Saxagliptin can be cleared through metabolism (21% -- 52% of the dose administered is recovered in the urine as major metabolites) and renal excretion (12% -- 29% of the dose administered is cleared in the urine as mother drug). A recent study evaluated the effects of renal insufficiency and hemodialysis on the pharmacokinetics of saxagliptin. In this study, the degree of renal insufficiency did not affect the Cmax of saxagliptin or its major metabolites. The mean global systemic exposure (AUC) of saxagliptin and its major metabolites in subjects with mild renal insufficiency was 1.2 times and 1.7 times higher than that in subjects with normal renal insufficiency, respectively. AUC values were 1.4 and 2.9 times higher in subjects with moderate renal insufficiency than in subjects with normal renal function, respectively. The corresponding values were 2.1 and 4.5 times, respectively, in subjects with severe renal insufficiency. Hemodialysis at 4 h can remove 23% of the dose of Sax. 
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