Pharmaceutical Grade Weight Loss Steroids AICAR Acadesine

AICAR Application

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AICAR is a peptide, it is a generation of inosinic acid in an intermediate, and metabolic regulation is directly related. The most important mechanism known to AICAR is its ability to block enzymes at both intracellular and extracellular levels, which in turn allows accelerated stimulation of glucose uptake and increased protein kinase in skeletal muscle tissue. These two functions allow more energy conversion, which helps to burn fat and maintain the output of the activity. Scientists and athletes / bodybuilders are interested in this.

AMP activates protein kinase

The main mechanism of AICAR is to activate AMPK (AMP-activated protein kinase). Thus, activating AMPK can make the same cellular mechanism (which can be said to be opened) as if cells were consumed by energy, such as strong exercise, or from low calorie intake.

A sufficient and considerable concentration of AICAR is effective in activating AMPK and inducing cell status as if it had been exercised or had low energy storage and therefore needed to burn fat.

AICAR uses metabolic pathways to block certain enzymes, which allow AMP to activate the protein kinase. This can be explained by the layman: Once you have taken a lot of AICAR, it deceives your body at the cellular level and thinks that this exercise has just finished. Since the body thinks that a considerable amount of exercise has just been carried out, the cellular energy cycle begins to transform the fuel source, such as fatty acids, to output the energy that is considered to be spent in motion. This can directly affect the level of endurance activity and the sustainability of the activity. Insulin sensitivity is also considered to be a behavior of AICAR, because the body will think that it is only experienced a series of exercises. Interestingly, in animal studies of obese mice, AICAR showed the benefits of all peptides in obese diet-induced mice while healthy lean mice did not gain any benefit of increased insulin sensitivity or increased glucose uptake. Having said that, fitness applications do not seem appropriate, because these mechanisms are for shape and overweight.

Prevent ischemic injury

Interestingly, AICAR has been shown to prevent ischemic injury. This type of damage is directly related to the limits of blood on the tissue, which may lead to the lack of oxygen and glucose required to keep tissue alive. This can lead to thrombosis, embolism and vasoconstriction. AICAR can be used as a stable peptide for ischemic attack and can allow appropriate blood flow to the heart (heart). This feature is very interesting because AICAR can be used fundamentally to treat heart attacks for heart muscles. This may reduce the likelihood of ischemic injury. In animal studies using peptide AICAR, abnormal growth in cardiac tissue and heart valve function has also changed, which is disadvantageous.

Product Features

AICAR (AICA-Riboside) strongly inhibits transcription of PPARα and co-activation of PPARα. It has been shown in adipocyte studies that antagonizing lipolysis induced by isoproterenol and has been suggested for kinase cascade studies. In addition, studies have shown that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies have shown that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase) and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is a monophosphorylated derivative of AICA-riboside which can be used as an aminoimidazole carboxamide ribonucleotide invertase / inosine monophosphate cyclase hydrolase ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 kinases.

AMP activates protein kinase (AMPK) as a metabolic sensor that regulates lipid and glucose metabolism, maintains cell homeostasis and protects against metabolic stress, a selective activator of AMPK in hepatocytes and adipocytes. At 0.5 mM, it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of the control and is in the 3T3-L1 Fat cells reduced by 2.5 times the GLUT4 translocation. It also blocked the expression of proinflammatory cytokines (TNF-α / IL-1β and IL-6), iNOS, COX-2 and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C / EBP pathways.

Biological activity

AICAR is a cell osmotic activator of AMP-activated protein kinase (AMPK), a metabolic major regulator that is activated when energy availability is reduced (high-cell AMP: ATP ratio) and is used to inhibit the metabolic process. In vivo, AMPK and AICAR pharmacological activation simulates exercise and triggers skeletal muscle independent of insulin glucose uptake.

AMP - activated protein kinase (AMPK) cells are permeable to allosteric activators. Enhance the proliferation, differentiation and mineralization of osteoblast MC3T3-EI cells and attenuate the expression of proinflammatory cytokines and iNOS in astrocytes induced by psychosis. Promote osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

AICAR / ACADESINE Usage

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain the steady state of cell energy (Hardie and Carling).

AICAR can play a role in promoting these processes because it contains the ability to penetrate the heart cells and prevent the production of enzymes associated with regulation of glucose intake and energy excretion. Inhibition of these regulatory enzymes, the affected cells, in turn, can increase the amount of acceptable glucose and also increase their energy conversion levels. In addition, the presence of peptides has been identified to help reduce programmed cell death, which is also known as apoptosis.