China SARMs Liquid manufacturer

Pharmaceutical Grade Weight Loss Steroids AICAR Acadesine

Product Details:
Place of Origin: shaanxi
Brand Name: xn
Certification: GMP,SGS,BV,ISO
Model Number: aicar
Payment & Shipping Terms:
Minimum Order Quantity: 1g
Price: Negotiable
Packaging Details: Aluminum foil bag, carton or more according to customer requirements
Delivery Time: Within 24 hours after payment
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: 3000kg/month

Detail Information

Name: Aicar Cas: 2627-69-2
Purity: 99.5% MW: 624.776
Molecular Formula: C27H36N4O5S.CH4O3S Usage: Bodybuilding&athletes Competition
Character: White Powder Place Of Origin: China
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Product Description

Weight Loss Steroids AICAR Acadesine Pharmaceutical Grade CAS 2627-69-2  

Quick detail

Product name: AICAR

 

Other name: Acadesine

 

CAS: 2627-69-2

 

Appearance: white powder

 

purity: 99%

 

Trademark: Pharmlab

 

Original: China

 

Grade: Pharmaceutical grade

 

Package: Disguised package ; Foil bag

 

Delivery date: 3-5 work days

 

Certificate: ISO 9001, USP,GMP

 

Payment: Western Union, MoneyGram, T/T, bitcoin

 

Shipping: EMS,HKEMS,EUB,ETK,FEDEX,DHL,UPS,Aramex,ETC

 

Policy: Re-Shipping Policy

 

M.W:258.23

 

Formula:C9H14N4O5

 

Solubility:Soluble to 75 mM in water and to 75 mM in DMSO

 

Storage:Store at -20°C

 

Ysage: AICAR is a nucleoside analog that is capable of entering a nucleotide pool and is capable of significantly increasing adenosine levels during ATP breakdown. Adenosine regulatory agents (ARAs) are considered to have therapeutic potential in myocardial ischemia. Heart protection.

Commerce Clause

Minimum Order Quantity: 1g
Price: Negotiable
Payment Terms: Western Union, MoneyGram, T/T, Bank Transfer;Bitcoin
Packaging Details: Discreet and Disguised packing
Delivery time: Within 24 hours after receiving the payment
Leading time: 4~6 working days after confirming the payment
Delivery By DHL, TNT, FedEx, HKEMS, UPS, etc.(Door to Door)bulk order can be negotiable
Tracking number can be offered to you within 24h
Supply Ability: Mass in stock

Aicar Introduction

AICAR is a peptide with the technical name of 5-aminoimidazole-4-carboxamide ribonucleotides. It can also be called AICA ribonucleotides, ZMP or Acadesine. It is an intermediate containing inosine monophosphate. It is primarily an AMP-activated protein kinase agonist, meaning it has the ability to promote nutrient storage for energy production. Molecular weight of 338.211, the formula for the C9H15N4O8P.

 

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain the steady state of cell energy (Hardie and Carling).

 

AICAR can play a role in promoting these processes because it contains the ability to penetrate the heart cells and prevent the production of enzymes associated with regulation of glucose intake and energy excretion. Inhibition of these regulatory enzymes, the affected cells, in turn, can increase the amount of acceptable glucose and also increase their energy conversion levels. In addition, the presence of peptides has been identified to help reduce programmed cell death, which is also known as apoptosis.

 

 

 

 

Pharmaceutical Grade Weight Loss Steroids AICAR Acadesine 0

 

Related SARMs and Usage:

name Usage
AICAR acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown
MK2866 medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testoserone Replacement Therapy.
MK-677 A growth hormone secretagogue, treatment of obesity, a promising therapy for the treatment of frailty in the elderly
LGD-4033 pharmacological profile similar to that of enobosarm, Ostarine,MK-2866
GW1516 For obesity, diabetes, dyslipidemia and cardiovascular disease
Andarine(S4) partial agonist, intended mainly for treatment of benign prostatic hypertrophy
SR9009 under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice
RAD140 New generation for gaining mass and cutting edges
YK11

a SARM and myostatin inhibitor in one

 

Pharmaceutical Grade Weight Loss Steroids AICAR Acadesine 1

AICAR Application

lose weight

AICAR is a peptide, it is a generation of inosinic acid in an intermediate, and metabolic regulation is directly related. The most important mechanism known to AICAR is its ability to block enzymes at both intracellular and extracellular levels, which in turn allows accelerated stimulation of glucose uptake and increased protein kinase in skeletal muscle tissue. These two functions allow more energy conversion, which helps to burn fat and maintain the output of the activity. Scientists and athletes / bodybuilders are interested in this.

 

AMP activates protein kinase

The main mechanism of AICAR is to activate AMPK (AMP-activated protein kinase). Thus, activating AMPK can make the same cellular mechanism (which can be said to be opened) as if cells were consumed by energy, such as strong exercise, or from low calorie intake.

A sufficient and considerable concentration of AICAR is effective in activating AMPK and inducing cell status as if it had been exercised or had low energy storage and therefore needed to burn fat.

AICAR uses metabolic pathways to block certain enzymes, which allow AMP to activate the protein kinase. This can be explained by the layman: Once you have taken a lot of AICAR, it deceives your body at the cellular level and thinks that this exercise has just finished. Since the body thinks that a considerable amount of exercise has just been carried out, the cellular energy cycle begins to transform the fuel source, such as fatty acids, to output the energy that is considered to be spent in motion. This can directly affect the level of endurance activity and the sustainability of the activity. Insulin sensitivity is also considered to be a behavior of AICAR, because the body will think that it is only experienced a series of exercises. Interestingly, in animal studies of obese mice, AICAR showed the benefits of all peptides in obese diet-induced mice while healthy lean mice did not gain any benefit of increased insulin sensitivity or increased glucose uptake. Having said that, fitness applications do not seem appropriate, because these mechanisms are for shape and overweight.

Prevent ischemic injury

Interestingly, AICAR has been shown to prevent ischemic injury. This type of damage is directly related to the limits of blood on the tissue, which may lead to the lack of oxygen and glucose required to keep tissue alive. This can lead to thrombosis, embolism and vasoconstriction. AICAR can be used as a stable peptide for ischemic attack and can allow appropriate blood flow to the heart (heart). This feature is very interesting because AICAR can be used fundamentally to treat heart attacks for heart muscles. This may reduce the likelihood of ischemic injury. In animal studies using peptide AICAR, abnormal growth in cardiac tissue and heart valve function has also changed, which is disadvantageous.

Product Features

AICAR (AICA-Riboside) strongly inhibits transcription of PPARα and co-activation of PPARα. It has been shown in adipocyte studies that antagonizing lipolysis induced by isoproterenol and has been suggested for kinase cascade studies. In addition, studies have shown that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies have shown that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase) and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is a monophosphorylated derivative of AICA-riboside which can be used as an aminoimidazole carboxamide ribonucleotide invertase / inosine monophosphate cyclase hydrolase ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 kinases.

 

AMP activates protein kinase (AMPK) as a metabolic sensor that regulates lipid and glucose metabolism, maintains cell homeostasis and protects against metabolic stress, a selective activator of AMPK in hepatocytes and adipocytes. At 0.5 mM, it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of the control and is in the 3T3-L1 Fat cells reduced by 2.5 times the GLUT4 translocation. It also blocked the expression of proinflammatory cytokines (TNF-α / IL-1β and IL-6), iNOS, COX-2 and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C / EBP pathways.

 

Biological activity

AICAR is a cell osmotic activator of AMP-activated protein kinase (AMPK), a metabolic major regulator that is activated when energy availability is reduced (high-cell AMP: ATP ratio) and is used to inhibit the metabolic process. In vivo, AMPK and AICAR pharmacological activation simulates exercise and triggers skeletal muscle independent of insulin glucose uptake.

 

AMP - activated protein kinase (AMPK) cells are permeable to allosteric activators. Enhance the proliferation, differentiation and mineralization of osteoblast MC3T3-EI cells and attenuate the expression of proinflammatory cytokines and iNOS in astrocytes induced by psychosis. Promote osteogenic differentiation of hAMSCs and BM-MSCs in vitro.

 

 

AICAR / ACADESINE Usage

 

AICAR is an adenosine analog that selectively activates AMP-activated protein kinase (AMPK). AMPK regulates lipid and glucose metabolism to maintain the steady state of cell energy (Hardie and Carling).

 

AICAR can play a role in promoting these processes because it contains the ability to penetrate the heart cells and prevent the production of enzymes associated with regulation of glucose intake and energy excretion. Inhibition of these regulatory enzymes, the affected cells, in turn, can increase the amount of acceptable glucose and also increase their energy conversion levels. In addition, the presence of peptides has been identified to help reduce programmed cell death, which is also known as apoptosis.

 

 

Pharmaceutical Grade Weight Loss Steroids AICAR Acadesine 2

Weight Loss Steroids AICAR Acadesine Pharmaceutical Grade CAS 2627-69-2

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