99% Purity White SR9011 Powder CAS 1379686-29-9

Product Description

99% Purity White SR9011 Powder CAS 1379686-29-9 2 Years Shelf Life

Abstract

SR9011 is a potent and specific synthetic REV-ERB agonist that binds to REV-ERB-α with an EC50 ~790nM and REV-ERB-β with EC50 ~560 nM. It also has good in vivo plasma/brain exposure. The nuclear receptors REV-ERB-α and REV-ERB-β play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.
Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

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Description
SR9011 is a trifunctional methacrylate monomer that provides exceptional adhesion to metal substrates. SR9011 is recommended for use in peroxide cured coatings, sealants, and PVC-based plastisols. Usage levels of 5% to 10% by weight are recommended.
The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure. Treatment of diet-induced obese mice with SR9011 decreased obesity by reducing fat mass and markedly improved dyslipidaemia and hyperglycaemia. These results indicate that synthetic REV-ERB ligands that pharmacologically target the circadian rhythm may be beneficial in the treatment of sleep disorders as well as metabolic diseases.

Application

Administration of SR9011 alters circadian behavior and the circadian pattern of core clock gene expression in the hypothalami of mice. The circadian expression pattern of an array of metabolic genes in the liver, skeletal muscle and adipose tissue was also altered, resulting in increased energy expenditure.

How It Works?

Studies have shown that sr9009 treatment can improve endurance and reverse mitochondrial damage.Sr9009 has great potential in improving exercise capacity and endurance.This compound acts as an agonist for Rev Erbα. Sr9009 binds to a native human molecule called Rev Erbα, It affects lipid and glucose metabolism in the liver, the production of fat storing cells, and the response of macrophages (cells that clear dead cells) during inflammation.The present study shows that Rev Erb is activated byα As sr9009 led to an increase in skeletal muscle metabolic activity, 50% of the running capacity increased both in time and distance in culture.Sr9009 is a convenient and metabolically active compound for oral administration.Sr9009 is locked onto Rev Erbα-- It plays an important regulatory role on the body's circadian rhythm and metabolism, thereby significantly enhancing the subject's metabolism.

SR9009 Dosages And Suggestion:

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