China SARMs Liquid manufacturer

Aicar Sarms Capsule Sarms Bodybuilding White Capsule

Product Details:
Place of Origin: shaanxi
Brand Name: xn
Certification: GMP,SGS,BV,ISO
Model Number: Aicar
Payment & Shipping Terms:
Minimum Order Quantity: 1g
Price: Negotiable
Packaging Details: Aluminum foil bag, carton or more according to customer requirements
Delivery Time: Within 24 hours after payment
Payment Terms: T/T, Western Union, MoneyGram,bitcoin
Supply Ability: 3000kg/month

Detail Information

Name: Aicar Cas: 2627-69-2
Molecular Formula: C9H14N4O5 Character: White Capsule
Usage: Bodybuilding&athletes Competition Purity: 99.5%
MW: 258.23 Delivery Time: Within 24 Hours After Payment
High Light:

xn Aicar SARMs Capsule

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2627-69-2 White capsule

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xn GMP SARMs Capsule

Product Description

Aicar Sarms Capsule Of Sarms Bodybuilding Supplements And Lgd Sarm

 

AICAR (AICA-Riboside) strongly inhibits the transcription of PPARα and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).

application:

(1) Aicar Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.
(2) Aicar Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
(3) Aicar Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.

Commerce Clause

Minimum Order Quantity: 1g
Price: Negotiable
Payment Terms: Western Union, MoneyGram, T/T, Bank Transfer;Bitcoin
Packaging Details: Discreet and Disguised packing
Delivery time: Within 24 hours after receiving the payment
Leading time: 4~6 working days after confirming the payment
Delivery By DHL, TNT, FedEx, HKEMS, UPS, etc.(Door to Door)bulk order can be negotiable
Tracking number can be offered to you within 24h
Supply Ability: Mass in stock

Aicar Sarms Capsule Sarms Bodybuilding White Capsule 0

HISTORY:

AICAR has been used medically to help with restriction of blood supply to tissues, called ischemia. Interestingly, in the 1980’s it was sometimes used during surgery to help preserve blood flow to the heart. These days, AICAR shows to be promising in diabetes treatment because of its ability to increase metabolic activity of tissues by changing the composition of muscles in the body.

What is AICAR?

AICAR is a peptide whose technical name is 5-Aminoimidazole-4-carboxamide ribonucleotide. It can also be known as AICA ribonucleotide, ZMP, or Acadesine. It is an intermediate contained in the generation of inosine monophosphate. It primarily functions as an AMP-activated protein kinase agonist, meaning that it has the ability to promote the operation of nutrient stores for energy production. It has a molecular mass of 338.211, and it has a molecular formula of C9H15N4O8P.

 

5-Aminoimidazole-4-carboxamide ribonucleotide (AICAR) is an intermediate in the generation of inosine monophosphate. AICAR is an analog of adenosine monophosphate (AMP) that is capable of stimulating AMP-dependent protein kinase (AMPK) activity. AICAR has been used clinically to treat and protect against cardiac ischemic injury.The drug was first used in the 1980s as a method to preserve blood flow to the heart during surgery.Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.

How it works ?

Acadesine is an analog of adenosine that enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia.In cardiac myocytes, acadesine is phosphorylated to AICAR to activate AMPK without changing the levels of the nucleotides. AICAR is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase in ATP levels and adenosine levels.

 

How AICAR Functions:

Scientific study based on animal test subjects has detmined that AICAR can play a hand in boosting these processes because it contains the ability to penetrate cardiac cells and block the production of enzymes tied to regulating glucose intake and energy expulsion. With these regulatory enzymes inhibited, the affected cells can in turn boost the amount of glucose that can be received, and it can also increase its level of energy conversion. Additionally, the peptide’s presence has been determined to aid in lowering programmed cell death, a process that is also known as apoptosis.

 

Ultimately, all of these elevated processes combine to provide an animal test subject an easier time in which it can achieve a level of homeostasis.

 

Applications and benefits:

 

Medical use:

A brief period of coronary arterial occlusion followed by reperfusion prior to prolonged ischemia is known as preconditioning. It has been shown that this is protective. Preconditioning preceded myocardial infarction, may delay cell death and allow for greater salvage of myocardium through reperfusion therapy.AICAR has been shown to precondition the heart shortly before or during ischemia.AICAR triggers a preconditioned anti-inflammatory state by increasing NO production from endothelial nitric oxide synthase.When AICAR is given 24 hours prior to reperfusion, it prevents post ischemic leukocyte-endothelial cell adhesive interactions with increased NO production. AICAR-dependent preconditioning is also mediated by an ATP-sensitive potassium channel and hemeoxygenase-dependent mechanism. It increases AMPK-dependent recruitment of ATP-sensitive K channels to the sarcolemma causing the action potential duration to shorten, and preventing calcium overload during reperfusion.The decrease in calcium overload prevents inflammation activation by ROS.AICAR also increases AMPK-dependent glucose uptake through translocation of GLUT-4 which is beneficial for the heart during post-ischemic reperfusion.The increase in glucose during AICAR preconditioning lengthens the period for preconditioning up to 2 hours in rabbits and 40 minutes in humans undergoing coronary ligation.As a result, AICAR reduces the frequency and size of myocardial infarcts up to 25% in humans allowing improved blood flow to the heart.As well, the treatment has been shown to decrease the risk of an early death and improve recovery after surgery from an ischemic injury.

Aicar Sarms Capsule Sarms Bodybuilding White Capsule 1

Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and
tacking number are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.
Please feel free to contact us. 24/7 online to solve your various problems!

 

Aicar Sarms Capsule Of Sarms Bodybuilding Supplements And Lgd Sarm

 

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