|Place of Origin:||shaanxi|
Payment & Shipping Terms:
|Minimum Order Quantity:||1g|
|Packaging Details:||Aluminum foil bag, carton or more according to customer requirements|
|Delivery Time:||Within 24 hours after payment|
|Payment Terms:||T/T, Western Union, MoneyGram,bitcoin|
|Molecular Formula:||C27H36N4O5S.CH4O3S||Character:||White Powder|
|MW:||624.776||Place Of Origin:||China|
Bodybuilding Aicar SARMs,
muscle gaining powder ISO,
OEM Aicar SARMs
Bodybuilding SARMs Raw Powder Aicar Acadesine For Muscle Gaining
AICAR (chemical name: 5-Aminoimidazole-4-carboxamide ribonucleotide) is a peptide, which is an intermediate within the generation of inosine monophosphate and directly related to metabolic regulation. The most important mechanism that AICAR is known for is its ability to block enzymes both in intracellular and extracellular levels, which, in turn, allows for an accelerated stimulation of glucose uptake and increase protein kinases in skeletal muscle tissue. These two functions allow for more energy conversion, which helps burn fat and also sustain output in activity. This is what scientists and athletes/bodybuilders are interested in, but there are some amazing side effects.
Interestingly, AICAR has been shown to protect against ischemic injury. This type of injury is directly related to the restriction of blood to tissues, which can cause insufficient amounts of oxygen and glucose needed to keep the tissue alive. This can lead to thrombosis, embolisms, and vasoconstriction. AICAR can be used as a stabilizing peptide for ischemic episodes, and it can allow for proper blood flow to the myocardium (heart). This function is very interesting, as AICAR could be fundamentally used to treat the heart muscle in the aftermath of a heart attack. This might reduce the possibility for ischemic injuries. Abnormal growths of heart tissues and heart valve function have also been altered in animal studies that used the peptide AICAR, which is a downside.
(1) Aicar Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.
(2) Aicar Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
(3) Aicar Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.
AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).
AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase. AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways
Related SARMs and Usage:
|AICAR||acts by entering nucleoside pools, significantly increasing levels of adenosine during periods of ATP breakdown|
|MK2866||medical prescription for prevention of cachexia, atrophy, and sarcopenia and for Hormone or Testoserone Replacement Therapy.|
|MK-677||A growth hormone secretagogue, treatment of obesity, a promising therapy for the treatment of frailty in the elderly|
|LGD-4033||pharmacological profile similar to that of enobosarm, Ostarine,MK-2866|
|GW1516||For obesity, diabetes, dyslipidemia and cardiovascular disease|
|Andarine(S4)||partial agonist, intended mainly for treatment of benign prostatic hypertrophy|
|SR9009||under development at The Scripps Research Institute (TSRI), increases the level of metabolic activity in skeletal muscles of mice|
|RAD140||New generation for gaining mass and cutting edges|
a SARM and myostatin inhibitor in one
Why do we need to use SARM ?
In general, SARMs offer three key benefits - increased muscle mass, decreased fat mass, and increased bone mass.
SARM aren't just designed and meant for athletes; as previously discussed there are a slew of populations that could benefit from SARMs.
Those with one or more of the following conditions could benefit from SARMs: muscle wasting disorders (such as : sarcopenia, amyotrophic lateral sclerosis, and cystic fibrosis), sports injuries, burn injuries, weakness and/or body wasting due to cancer or HIV, and frailty and/or muscle atrophy as a result of the aging process.
Although there are many drugs designed to improve the health of these populations, SARMs also have the unique benefit of being non-methylated and non-aromatized by the body, so they're not toxic to the liver nor do they convert in to other active androgen or estrogen compounds. Liver toxicity and aromatization is a very serious concern when using pro-hormones and AASs. As you can see, SARMs benefit both chronically ill individuals as well healthy individuals looking to maximize quality of life.
Furthermore, SARM have demonstrated the ability to minimize or prevent muscle trophy when muscles were immobilized in casts. This is great news for athletes who work hard on the field and in the weight room to build muscle mass, strength, and power as SARM may positively impact the recovery process.
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Bodybuilding SARMs Raw Powder Aicar Acadesine For Muscle Gaining
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