Sitagliptin antidiabetics High purity of LGD 4033 Ligandrol

Product Description

Aicar Acadesine Fat Burning SARMs Raw Powder CAS 2627-69-2

Descrption

Product Description

LGD-4033 is a selective androgen receptor modulator, a compound that targets specific androgen receptors in the body. Its main function is to increase muscle growth and bone density. It was originally developed for the treatment of muscle atrophy and bone density. Conditions such as osteoporosis, discovered by Ligand Pharmaceuticals and currently being developed by Viking Therapeutics, many studies have confirmed that LGD-4033 can help build muscle mass without a ton of side effects, nor is it highly depressive like testosterone, which means you can Cycle without worrying about long-term downtime.

(1) Before clinical medical use

At 13 weeks daily doses of 0 to 75 mg/kg, both male and female cynomolgus monkeys experienced significant increases in body weight, but after 48 days the dose was significantly higher than that used in the phase 2 clinical trial. Yes, the 75 mg/kg dose test was discontinued, but this did not negatively affect the development of the animals.

(2) Clinical trials

In a phase 1 clinical trial of 76 adult men, observed through different supply doses, the change in the user's net weight gain was positively correlated with the supply dose, and no obvious side effects occurred under the 21-day test.

The Phase 2 clinical trial, which started on November 3, 2015, was administered to 120 patients after hip fracture surgery. The subjects were divided into placebo and different doses of LGD-4033 during the 12-week test. The changes in net body weight, quality of life, safety and pharmacokinetics were observed, all showing satisfactory results.

2. Is LGD-4033 safe?

Over the past few years, many studies have noted that LGD-4033 is minimally toxic to the body, with increases in subjects' net body weight (muscle) and bone density, and mild autologous testicular suppression when taken for extended periods of time solid secretion.

The side effects part of it, there aren't many studies that show it, LGD doesn't seem to cause any hair loss or male pattern baldness, in clinical trials, prostate size was shown to be unaffected, and also because all SARMs don't convert to estrogen, so LGD-4033 also does not cause gynecomastia problems.

3. What can be expected to be obtained by using LGD-4033?

(1) Helps prevent osteoporosis:

LGD-4033 has a positive effect on BMD by increasing periosteal bone formation, which helps maintain bone mass while reducing muscle loss.

(2) Prevention of cancer or malignant disease (Cachexia):

Malignant diseases are known to be very common in patients suffering from cancer, AIDS, and kidney disease, among others. Using this will prevent it from happening, as LGD-4033 is known for increasing muscle mass and enhancing muscle strength. In this way, it is able to reduce the chance of developing a malignant disease in these individuals.

(3) Increase muscle mass:

Want to get a muscular body? Using this to gain better muscle mass is now very simple. This is because the supplement will enable your body to experience increased energy production and blood circulation, which can play a greater role in muscle building.

(4) Increase body energy:

One of the key functions of this is to increase your body's metabolism, meaning your body will be able to burn a lot of fat, which is converted into energy, which can also improve other body functions such as breathing and digestion.

(5) Helps to reduce fat:

LGD-4033 has also been found to play an important role in enhancing weight loss, as it works by improving muscle strength, which means your body burns more calories, and when they are converted into energy, it creates more energy Multiple calorie deficits while protecting muscle from being broken down during fat loss.

(6) Increase muscle strength:

For LGD-4033, which prevents any muscle loss that can lead to osteoporosis, it works by strengthening bone density and also provides a strength boost by increasing the body's energy.

(7) Improve sexual performance:

Many erectile dysfunctions, such as premature ejaculation, can be addressed with LGD-4033, which will have a positive effect on your sex life.

Dosage

Doses range from 150 milligrams (mg) per day (if stacked with GW), up to 500 milligrams per day when used alone. This is quite expensive considering that each bottle usually has a 50mg dose, as mentioned above. Financially, it makes the most sense to run AICAR in the 4 weeks before the race.

Function

AICAR strongly inhibits the transcription of PPAR&alpha and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK, and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC). AICAR is an inhibitor of Hsp90, mTOR and p70 S6 Kinase.

AMP-activated protein kinase (AMPK) functions as a metabolic sensor that regulates lipid and glucose metabolism to maintain cellular energy homeostasis and to protect against metabolic stress.AICAR is a selective activator of AMPK in both hepatocytes and adipocytes. At 0.5 mM it inhibits the synthesis of fatty acids and sterols and inactivates HMG-CoA reductase in rat hepatocytes.AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of controls and reduces GLUT4 translocation 2.5-fold in 3T3-L1 adipocytes. It also blocks the expression of pro-inflammatory cytokines (TNF-α/IL-1β and IL-6), iNOS, COX-2, and MnSOD genes in glial cells and macrophages by inhibiting NFκB and C/EBP pathways.

Our Competitive Advantages:
 

1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!

Specification

FAQ

Question 1 , How do you pack the order ?
Discreet package , the packing suits you best would be choosen to cross customs safely

Question 2 , What is your shipping method ?
Shipping by express (FedEx,UPS,DHL,EMS,HKEMS,TNT), and cheapest by airmail

Question 3 , if my order seized by custom ,what do you do ?
Resending police if the tracking number do not update online or it sezied by custom

Questions 4 , What is your payment accept ?
Safe and fast payment :Western Union ,Money Gram ,T/T ,Bitcoin

Questions 5 , Will you supply tracking number ?
Yes ,we supply tracking number for following .In general ,once we supply the tracking number to you ,you can track the parcel information within 1-2 business days

Question 6 , How many days will it take to my country after I do the payment ?
In general ,fastest with 3-5 business , slowest 5-7 business days